The purpose of this guide is to provide an overview of Genetic Analysis and help to guide you in carrying out the analysis. The site is divided into sections with advice on study design, using MS-DOS and LINUX, the theory and principles behind the tests you are going to carry out, and running various genetic analysis programs.
The majority of the information presented here is just a re-hash of the manuals and documentation that accompany the various programs described, (although hopefully I've made it a bit simpler to understand). If it is your intention to use the programs documented here then it is strongly recommended that you read the documenation that accompanies the program, and the original research paper describing the statistics and algorithms implemented in the programs if you wish to be able to interpret the results fully.
Before carrying out any analysis you should have a clear idea of the question you are asking and an understanding of the meaning of statistical significance. Please read the section on hypothesis testing .
I have where appropriate provided references to original works and useful reading, and links to resources that are available over the Internet.
I have whilst writing these pages attempted to organise subjects and information into intuitive groups of subjects and provide links where appropriate, however it may not seem that way. Thus in order to help you find information on this web-site you can follow the instructions here on how to use Google to search this site.
You can find details of our research interests and work at the Arthritis Research Campaign web-site, and here.
If you have any feedback about the web-site and its content (eroneous information, important things missing, broken links, etc.) please let me know by sending an email to neil.shephard@man.ac.uk, although theres no guarentee how quickly I'll be able to rectify them.
If you work within the ARC/CIGMAR/UCDE the we are available to discuss study design and analysis issues.
This web-site was created using Emacs with the Html-helper mode, and the HTML editor Bluefish.
Thanks to Google the search box below allows you to search this site (or the web).
I have decided to apply the GFDL licence to these pages, making them free for all to use. The main impetus for this was the suggsteion by Magnus Manske to port these pages to Wikibooks, a process which will begin in due course. Once established feel free to help port these page sto wikibooks. Neil
Copyright (c) 2008 Neil Shephard. Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled "GNU Free Documentation License".